🌿 Cell Cleanup, More Oomph

One Capsule, Longer Walks

August 28, 2025 • Estimated Reading Time: 6 minutes

By 3 p.m., coffee stopped helping and the walk to the corner shop felt like a hill. Eight weeks after a mitochondria-first tweak, that same walk felt easy and my legs didn’t complain.

In partnership with

Learn from this investor’s $100m mistake

In 2010, a Grammy-winning artist passed on investing $200K in an emerging real estate disruptor. That stake could be worth $100+ million today.

One year later, another real estate disruptor, Zillow, went public. This time, everyday investors had regrets, missing pre-IPO gains.

Now, a new real estate innovator, Pacaso – founded by a former Zillow exec – is disrupting a $1.3T market. And unlike the others, you can invest in Pacaso as a private company.

Pacaso’s co-ownership model has generated $1B+ in luxury home sales and service fees, earned $110M+ in gross profits to date, and received backing from the same VCs behind Uber, Venmo, and eBay. They even reserved the Nasdaq ticker PCSO.

Paid advertisement for Pacaso’s Regulation A offering. Read the offering circular at invest.pacaso.com. Reserving a ticker symbol is not a guarantee that the company will go public. Listing on the NASDAQ is subject to approvals.

Mitochondria reset, in plain words

Your cells make energy inside tiny power units called mitochondria. They work better when the cell clears out tired parts, a cleanup process called mitophagy. Urolithin A helps nudge that cleanup along in humans, not just in lab animals. Read the simple explainer and data from a human trial: See how researchers measured mitophagy.

The headliner: Urolithin A

In a randomized trial with adults in their late 60s to 80s, 1,000 mg daily for 4 months improved muscle endurance and shifted blood markers tied to mitochondrial health. Skim the study highlights: This 4-month trial surprised researchers. Another trial in middle-aged adults found stronger legs and better walking tests with 500–1,000 mg daily: See the strength gains. Early human data also show a drop in ceramides linked with heart risk: Why this marker drop matters.

How to start

Pick a brand that uses third-party testing. Look for the USP Verified mark so the capsule matches the label: How to spot a trusted seal. Typical study doses range from 500 to 1,000 mg per day. Take it with a light meal and give it 8–12 weeks. Keep a simple log of energy and walking ease.

Start learning AI in 2025

Keeping up with AI is hard – we get it!

That’s why over 1M professionals read Superhuman AI to stay ahead.

  • Get daily AI news, tools, and tutorials

  • Learn new AI skills you can use at work in 3 mins a day

  • Become 10X more productive

Smart pairings that stay simple

CoQ10 can support cellular energy. Evidence for muscle aches on statins is mixed, but a broad review suggests CoQ10 helps with general fatigue in some people. Read a neutral overview and a research summary: What NCCIH says about CoQ10 and Fatigue review in plain English. PQQ has early human data with exercise showing shifts in mitochondrial markers. Peek at the trial details: PQQ plus training study. Add only one helper at a time.

Safety first

Talk with your clinician before starting if you use blood thinners like warfarin, insulin, or cancer treatments. CoQ10 can interact with these. Review a short safety list: NCCIH safety notes. Stick with third-party-tested products and keep doses on the label.

Put extra energy to work

Pair urolithin A with easy movement. Aim for 150 minutes a week of brisk walking plus two short strength sessions. Break it into 10–15 minute bites if that feels better. Build a simple plan with this guide: CDC walking targets made simple.

Takeaway

Try urolithin A daily for 8–12 weeks, choose tested brands, add one helper at a time, and turn the extra energy into gentle walks.

Daily News for Curious Minds

Be the smartest person in the room by reading 1440! Dive into 1440, where 4 million Americans find their daily, fact-based news fix. We navigate through 100+ sources to deliver a comprehensive roundup from every corner of the internet – politics, global events, business, and culture, all in a quick, 5-minute newsletter. It's completely free and devoid of bias or political influence, ensuring you get the facts straight. Subscribe to 1440 today.